$76.5
$109.4
May 30 – 31 – 2025 – Internet Live Activity – Jacksonville, Florida The Mayo Clinic RNA Discoveries and Therapeutics Conference 2025 will convene experts in the areas of RNA Biology and RNA Therapeutics Development and Application in disease areas including but not limited to neurological diseases, cancer and rare diseases. It will help identify gaps and opportunities in this field to leverage RNA therapeutics from discovery to translation to clinical trials. Target Audience This course is relevant for physicians and other healthcare providers specializing in oncology, neurology, rare diseases, and metabolic specialties. The content also benefits individuals involved in cancer research, neurological studies, the development of RNA-based therapeutics, and clinical trial coordinators. Learning Objectives Upon completion of this activity, participants should be able to: Review the current state of RNA therapeutics to include their discovery and translation into practice Assess existing approaches to the discovery of RNA targets Identify gaps in the development of RNA therapies for common complex and rare diseases Assess existing approaches to the development of novel therapies to include treatment and delivery modalities Identify future opportunities for development of RNA therapies in common complex and rare diseases FRIDAY MAY 30, 2025 7:30AM Registration & Breakfast 8:00AM Welcome Kent R. Thielen, M.D. 8:05AM Mayo Clinic Research Alfredo Quinones-Hinojosa, M.D 8:10AM Mayo Clinic RNA Program Nilüfer Ertekin-Taner, M.D., Ph.D. 8:30AM Discovery of RNA-Targeting Compounds and Implications for Human Diseases Blanton Tolbert, Ph.D. (University of Pennsylvania, HHMI) 9:30AM Break/Exhibit Hall 9:45AM Harnessing RNA Biology Towards Therapies Haidong Dong, M.D., Ph.D. (Mayo Clinic) Jane Zhu, M.D., Ph.D. (Mayo Clinic) Jeff Coller, Ph.D. (Johns Hopkins University) Xiling Shen, Ph.D. (MD Anderson Cancer Center) 10:45AM Short talks selected from submitted abstracts 11:45AM Lunch/Exhibit Hall 12:45PM Advances in Translation of RNA Therapies to the Clinic Keith Gagnon, Ph.D. (Wake Forest University School of Medicine) Julie Allickson, Ph.D. (Mayo Clinic) Keith Knutson, Ph.D. (Mayo Clinic) Robert DeLong, Ph.D. (Landmark Bio) 1:45PM RNA Therapeutics from Bench to Bedside: Moderna Experience Patrick Finn, Ph.D. (Moderna) 2:30PM RNA Therapeutics: From Design to ASO Candidates Jeff Milton (La Jolla Labs) 3:00PM Break/Exhibit Hall 3:30PM Accelerating RNA Therapies Towards the Clinic – Lessons Learned from Industry Jay Parrish, Ph.D. (Pretzel Therapeutics) Susan Catalano, Ph.D. (Circle Biopharma) Claes Wahlestedt, M.D., Ph.D. (University of Miami) Andrew J. Geall, Ph.D. (Alliance for mRNA Medicines) Kate Broderick, Ph.D. (Maravai LifeSciences) Roberta Duncan (Arcturus Therapeutics) 4:45PM Adjourn 5:00PM – 6:30PM Reception & Poster Exhibition SATURDAY MAY 31, 2025 7:30AM Breakfast 7:55AM Welcome Nilüfer Ertekin-Taner, M.D., Ph.D. & Alfredo Quinones-Hinojosa, M.D. 8:00AM Clinical Translation of Therapeutic RNA Nano-vaccines for Cancer Natalie Silver, M.D. (Cleveland Clinic) 9:00AM Break/Exhibit Hall 9:15AM Applications of RNA Therapeutics and Diagnostics in Common and Rare Diseases Ken Yamada, Ph.D. (UMass Chan Medical School) Marlen Lauffer, M.D. (Dutch Center for RNA Therapeutics) Margot Cousin, Ph.D. (Mayo Clinic) Minerva Carrasquillo, Ph.D. (Mayo Clinic) Tsuneya Ikezu, M.D., Ph.D. (Mayo Clinic)10:15AMShort talks selected from submitted abstracts10:45AM Industrializing the Non-Profit ASO Treatment of Nano-Rare Patients Amy Williford, Ph.D. (n-Lorem Foundation) 11:45AMLunch/Exhibit Hall12:45PMArgonauts and RNA Therapies Phillip Zamore, Ph.D. (UMass Chan School of Medicine) 1:45PMDisruption of RNA Metabolism in Neurodegeneration and Pathway to Treatments Don W. Cleveland, Ph.D. (University of California San Diego) 2:45PMBreak/Exhibit Hall3:00PMDesigning RNA Therapies-Advances and Considerations in Data Analytics Alper Kucukural, Ph.D. (UMass Chan Medical School) Xue Wang, Ph.D. (Mayo Clinic) Yan Asmann, Ph.D. (Mayo Clinic) Richard Braatz, Ph.D. (MIT) 4:00PMClosing Remarks/Adjourn
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